The State of Mushroom & Psychedelic Research: September 2026

The big picture. ShroomWire is tracking 2407 mushroom & psychedelic studies, each graded A–F for evidence strength. Here’s where the evidence actually stands right now — including how much is still early-stage, what’s preprint, and what’s been retracted.

Evidence strength across what we track

Most of the field is still early — and we think saying so plainly is the point.

What’s being researched

Early-signal & integrity watch

• 286 tracked items are preprints (not yet peer-reviewed) — promising but provisional.
• 0 are flagged retracted and are never presented as standing evidence.

Most notable studies right now

• The Effectiveness of Interoceptive-Based Interventions to Reduce Adult Anxiety Sensitivity: A Systematic Review — Grade A · Occupational Therapy In Health Care
• Pilot study comparing the effects of high dose THC to high dose psilocybin and placebo in the set and setting of a class — Grade B · Psychopharmacology
• Publication bias in randomized trials of psilocybin for depression: a Robust Bayesian Meta-Analysis — Grade A · Preprint (PsyArXiv)
• Distinct brain responses to psilocybin and escitalopram in depression captured by the Fluctuation-Dissipation Theorem — Grade B · Preprint (bioRxiv)
• Prolonged Grief Symptom Outcomes During At-Home Ketamine-Assisted Therapy: A Real-World Retrospective Analysis of 503 Ad — Grade B · Preprint (Research Square)
• Evaluating the Role of Psilocybin Monitors in Psilocybin Therapy for Treatment Resistant Depression — Grade B · ClinicalTrials.gov
• CSF galanin and noradrenaline downregulation by psilocybin therapy in major depressive disorder. — Grade B · Europe PMC
• Music Playlist Use in Clinical Trials of Psychedelic Assisted Psychotherapy: A Systematic Review. — Grade A · Europe PMC
• Psilocybin-Assisted Therapy for Alcohol Use Disorder: A Systematic Review of Clinical Evidence — Grade A · Psychoactives
• Low doses of psilocybin as adjunct pharmacological treatment to virtual reality exposure therapy for social anxiety diso — Grade B · Preprint (PsyArXiv)

Methodology: see how we grade the evidence. This is a living snapshot, regenerated regularly from our research database. Explore every study in the Evidence Explorer.

## Educational Disclaimer

This article is for informational and educational purposes only. It is not
medical advice, mental health advice, diagnosis, treatment guidance, or a
recommendation to use any substance, supplement, therapy, or protocol.

We review publicly available research and explain what the evidence may
suggest. Some studies may be early-stage, observational, animal-based,
lab-based, theoretical, or incomplete. Always consult a qualified
professional before making health-related decisions.