The State of Mushroom & Psychedelic Research: August 2026

The big picture. ShroomWire is tracking 2386 mushroom & psychedelic studies, each graded A–F for evidence strength. Here’s where the evidence actually stands right now — including how much is still early-stage, what’s preprint, and what’s been retracted.

Evidence strength across what we track

Most of the field is still early — and we think saying so plainly is the point.

What’s being researched

Early-signal & integrity watch

• 276 tracked items are preprints (not yet peer-reviewed) — promising but provisional.
• 0 are flagged retracted and are never presented as standing evidence.

Most notable studies right now

• Psilocybin-assisted therapy for major depressive disorder: Perspective from meta-analysis. — Grade A · Europe PMC
• A Systematic Review of EEG Predictors and Correlates of Psilocybin’s Treatment in Depression — Grade A · Undergraduate Research in Natural and Clinical Science and Technology (URNCST) Journal
• A scoping review: ketamine or esketamine when used to assist psychotherapy or in combination with psychotherapy for the — Grade B · npj Mental Health Research
• Publication bias in randomized trials of psilocybin for depression: a Robust Bayesian Meta-Analysis — Grade A · Preprint (PsyArXiv)
• Distinct brain responses to psilocybin and escitalopram in depression captured by the Fluctuation-Dissipation Theorem — Grade B · Preprint (bioRxiv)
• Aquahenosis: A non-pharmacological altered state of consciousness induced by Floatation-REST in individuals with anxiety — Grade B · Preprint (PsyArXiv)
• Prolonged Grief Symptom Outcomes During At-Home Ketamine-Assisted Therapy: A Real-World Retrospective Analysis of 503 Ad — Grade B · Preprint (Research Square)
• Imaging the Effects of Serotonin 2A Receptor Modulation on Synaptic Density in Treatment-resistant Depression (SYNVEST) — Grade B · ClinicalTrials.gov
• Treatment With Psilocybin for Chronic Neuropathic Pain and Depression (TRANSCEND) — Grade B · ClinicalTrials.gov
• Evaluating the Role of Psilocybin Monitors in Psilocybin Therapy for Treatment Resistant Depression — Grade B · ClinicalTrials.gov

Methodology: see how we grade the evidence. This is a living snapshot, regenerated regularly from our research database. Explore every study in the Evidence Explorer.

## Educational Disclaimer

This article is for informational and educational purposes only. It is not
medical advice, mental health advice, diagnosis, treatment guidance, or a
recommendation to use any substance, supplement, therapy, or protocol.

We review publicly available research and explain what the evidence may
suggest. Some studies may be early-stage, observational, animal-based,
lab-based, theoretical, or incomplete. Always consult a qualified
professional before making health-related decisions.