The State of Psilocybin Research

The big picture. ShroomWire is tracking 105 psilocybin studies, each graded A–F for evidence strength. Here’s where the evidence actually stands right now — including how much is still early-stage, what’s preprint, and what’s been retracted.

Evidence strength across what we track

Most of the field is still early — and we think saying so plainly is the point.

Early-signal & integrity watch

• 25 tracked items are preprints (not yet peer-reviewed) — promising but provisional.
• 0 are flagged retracted and are never presented as standing evidence.

Most notable studies right now

• Psilocybin-assisted therapy for major depressive disorder: Perspective from meta-analysis. — Grade A · Europe PMC
• Examining the effects of psilocybin-assisted psychotherapy on anhedonia in treatment-resistant depression. — Grade B · Europe PMC
• Spatiotemporal mapping of brain organisation following the administration of 2C-B and psilocybin. — Grade B · Europe PMC
• Safety and Efficacy of Psilocybin in the Management of Treatment-Resistant Depression: A Systematic Review — Grade A · Preprint (Research Square)
• Mystical but Not Challenging Experiences Predict Symptom Improvement After Psilocybin for Treatment-Resistant OCD — Grade B · Preprint (PsyArXiv)
• Safety and Efficacy of Microdosing Psilocybin over 8 Weeks for Major Depressive Disorder: A Randomized Clinical Trial — Grade B · Preprint (Research Square)
• Microdosing Psilocybin for Major Depressive Disorder: Study Protocol for a Phase II Double-Blind Placebo-Controlled Rand — Grade B · Preprint (PsyArXiv)
• Ketamine and Psilocybin Differentially Impact Sensory Learning During the Mismatch Negativity — Grade B · Preprint (bioRxiv)
• Low doses of psilocybin as adjunct pharmacological treatment to virtual reality exposure therapy for social anxiety diso — Grade B · Preprint (PsyArXiv)
• Safety and Efficacy of Psilocybin-Assisted Therapy for Alcohol Use Disorder: Open-Label Extension of a Phase II Randomiz — Grade B · Preprint (PsyArXiv)

Methodology: see how we grade the evidence. This is a living snapshot, regenerated regularly from our research database. Explore every study in the Evidence Explorer.

## Educational Disclaimer

This article is for informational and educational purposes only. It is not
medical advice, mental health advice, diagnosis, treatment guidance, or a
recommendation to use any substance, supplement, therapy, or protocol.

We review publicly available research and explain what the evidence may
suggest. Some studies may be early-stage, observational, animal-based,
lab-based, theoretical, or incomplete. Always consult a qualified
professional before making health-related decisions.

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