The State of Mushroom & Psychedelic Research: June 2026
The big picture. ShroomWire is tracking 1531 studies across mushrooms, psychedelics, and brain-health research, each graded A–F for evidence strength. Here’s where the evidence actually stands this month — including how much is still early-stage, and what’s been retracted.
Evidence strength across everything we track
Most of the field is still early — and we think saying so plainly is the point.
What’s being researched
Early-signal & integrity watch
- 239 tracked items are preprints (not yet peer-reviewed) — promising but provisional.
- 0 are flagged retracted and are never presented as standing evidence.
Most notable studies right now
- Reduced task-switching flexibility in parietal-cingulate and frontal circuits associated with brooding. — Grade D · Europe PMC
- The role of therapeutic alliance in psilocybin treatment for treatment-resistant depression: A post hoc path analysis. — Grade D · Europe PMC
- Psilocybin-assisted therapy for major depressive disorder: Perspective from meta-analysis. — Grade A · Europe PMC
- Psychedelics as a potential treatment for borderline personality disorder: A narrative review. — Grade D · Europe PMC
- Psychedelics for treatment of negative symptoms and depressive symptoms in schizophrenia spectrum disorder: A narrative — Grade D · Europe PMC
- Psilocybin-assisted cognitive behavioral therapy for major depressive disorder: A pilot trial. — Grade D · Europe PMC
- Examining the effects of psilocybin-assisted psychotherapy on anhedonia in treatment-resistant depression. — Grade B · Europe PMC
- Spatiotemporal mapping of brain organisation following the administration of 2C-B and psilocybin. — Grade B · Europe PMC
- Rapid antidepressant potential of nitrous oxide: current state and major questions. — Grade C · Europe PMC
- Safety and Efficacy of Psilocybin in the Management of Treatment-Resistant Depression: A Systematic Review — Grade A · Preprint (Research Square)
Methodology: see how we grade the evidence. This is a living snapshot, regenerated regularly from our research database.
## Educational Disclaimer
This article is for informational and educational purposes only. It is not
medical advice, mental health advice, diagnosis, treatment guidance, or a
recommendation to use any substance, supplement, therapy, or protocol.
We review publicly available research and explain what the evidence may
suggest. Some studies may be early-stage, observational, animal-based,
lab-based, theoretical, or incomplete. Always consult a qualified
professional before making health-related decisions.