Can Lion’s Mane Mushrooms Actually Improve Memory in Healthy People?

Bottom line: A 2023 study suggests lion’s mane may be associated with slight improvements in reaction times and attention in healthy adults, but evidence for significant memory enhancement remains limited.

In a 2023 study, healthy adults who took lion’s mane extract showed slightly faster reaction times on a memory test — but not much else. That’s the most direct answer to the question: does lion’s mane improve memory in healthy people? Probably not in a way that shows up on the most important measures.

The mushroom — Hericium erinaceus — has been used in traditional Chinese medicine for centuries. Researchers are interested in it because it contains compounds like polysaccharides and hericenones, which may influence nerve growth factor (NGF). NGF is important for keeping neurons alive and helping them grow. This is why lion’s mane has drawn attention in the context of neurodegenerative diseases.

But the research is still mostly in animals or cells. Human studies are rare and small. The 2023 trial compared lion’s mane extract to a placebo and to guayusa tea — another plant used for cognitive support. Participants who took lion’s mane did better on some tests, like the Serial 7s, which checks attention and working memory. They also had faster reaction times in the N-Back test, which measures short-term memory and mental flexibility.

Still, the changes weren’t large, and the study didn’t find a clear improvement in memory recall — the key measure of memory function. People who took lion’s mane also reported feeling more alert and focused, but it’s not clear whether that was due to the mushroom or the belief that they were taking something special.

This brings up a bigger issue: the placebo effect. People who believe they’re taking a supplement that improves memory often report feeling better, even if the supplement has no real impact. In the 2023 study, the placebo group also felt more alert and focused, which suggests that belief might be a big part of the story.

Even if lion’s mane doesn’t improve memory, it might still help the brain in other ways. It has anti-inflammatory properties, which could be useful for people with neurological conditions. It also contains antioxidants, which help protect brain cells from damage. These benefits are more relevant for people with neurodegenerative diseases, but they might still help maintain brain function as people age.

But there are still many unknowns. Most studies are small or short-term, so we don’t know if lion’s mane has long-term benefits. We also don’t know how it interacts with other factors like sleep or exercise, or how its effects vary by age, gender, or genetics.

Lion’s Mane is generally considered safe. But as with any supplement, it’s worth talking to a doctor before taking it — especially if you have health conditions or are on medications. Some people might experience stomach issues or allergic reactions.

What’s clear is that the science is still early. The mushroom has shown some promise, but the evidence doesn’t yet support the idea that it significantly improves memory in healthy people. More research is needed before we can say for sure.

Frequently Asked Questions

Q: Can lion’s mane improve memory in healthy people?
A: There’s no strong evidence that lion’s mane improves memory in healthy people. Most studies show modest or no significant cognitive improvements, and many benefits may be due to placebo effects or subjective perception.

Q: Is lion’s mane safe to take?
A: Yes, lion’s mane is generally safe for most people. However, it’s important to consult with a healthcare provider, especially if you have underlying health conditions or are taking medications.

Q: How long does it take for lion’s mane to work?
A: Effects can vary, but most studies suggest that consistent use over several weeks may be needed to see any changes in cognitive function.

Q: Can lion’s mane be used as a treatment for Alzheimer’s or other neurodegenerative diseases?
A: While lion’s mane shows promise in animal studies, there is no conclusive evidence that it can treat or prevent neurodegenerative diseases in humans. More research is needed.

Q: Are there any side effects of taking lion’s mane?
A: Lion’s Mane is generally well-tolerated, but some people may experience gastrointestinal discomfort or allergic reactions. It’s important to start with a low dose and monitor how your body responds.

Sources

• ¶Mushrooms as future generation healthy foods.
• ¶Acute Effects of Naturally Occurring Guayusa Tea and Nordic Lion’s Mane Extracts on Cognitive Performance.
• ¶Enriching the Mediterranean diet could nourish the brain more effectively.
• ¶Interventions of natural and synthetic agents in inflammatory bowel disease, modulation of nitric oxide pathways.

Educational Disclaimer

This article is for informational and educational purposes only. It is not medical advice, mental health advice, diagnosis, treatment guidance, or a recommendation to use any substance, supplement, therapy, or protocol.

We review publicly available research and explain what the evidence may suggest. Some studies may be early-stage, observational, animal-based, lab-based, theoretical, or incomplete. Always consult a qualified professional before making health-related decisions.

Researched and drafted by Spore, ShroomWire’s AI research assistant, and reviewed by the ShroomWire editorial team before publishing.